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Related Experiment Video

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Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
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Directional Reaching for Water as a Cortex-Dependent Behavioral Framework for Mice.

Gregorio Luis Galiñanes1, Claudia Bonardi1, Daniel Huber1

  • 1Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.

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|March 8, 2018
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Summary
This summary is machine-generated.

Researchers developed a new behavioral task for mice, enabling directional reaching similar to primates. This allows for advanced studies of brain activity, motor control, and sensory processing in mice using optogenetics and imaging.

Keywords:
behaviordirectional reachinghead-fixedmotor cortexmouseoptogenetic inactivationtwo-photon imagingwater

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Systems Neuroscience

Background:

  • Advanced optogenetic and imaging tools have revolutionized neuroscience.
  • Existing behavioral paradigms for mice are less sophisticated than primate models, hindering the application of these tools.
  • A need exists for mouse behavioral tasks that facilitate detailed study of motor control and neural circuits.

Purpose of the Study:

  • To introduce an innovative behavioral framework for head-fixed mice that mimics primate reaching tasks.
  • To investigate motor control, sensory processing, and decision-making in mice using this new paradigm.
  • To enable simultaneous behavioral, optogenetic, and imaging studies in mice.

Main Methods:

  • Developed a head-fixed mouse reaching task where animals reach for water droplets.
  • Utilized optogenetics for targeted manipulation of neural circuits (e.g., motor cortex inactivation).
  • Employed layer 2/3 two-photon imaging to record neural activity during reaching movements.
  • Introduced vibratotactile stimuli to instruct directional reaching.

Main Results:

  • Mice rapidly learned and performed directional reaching tasks, engaging in hundreds of trials.
  • Mice demonstrated the use of chemosensation to detect water droplets.
  • Optogenetic inactivation of the motor cortex disrupted movement initiation and trajectory.
  • Two-photon imaging revealed significant direction selectivity in motor cortex neurons during reaching.

Conclusions:

  • The developed behavioral framework is effective for studying motor control in mice.
  • This paradigm allows for the investigation of sensory guidance (chemosensation, vibratotactile) in motor tasks.
  • The framework supports integrated studies of neural circuits underlying movement, sensation, and decision-making in mice.