Related Experiment Video

Updated: Feb 13, 2026

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
10:50

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

1.4K

Hypothalamic endoplasmic reticulum stress as a key mediator of obesity-induced leptin resistance

Z Ye1,2, G Liu3, J Guo1

  • 1Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), Guangdong Pharmaceutical University, Guangzhou, China.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|March 8, 2018
PubMed

Insights

Obesity is linked to endoplasmic reticulum stress, causing leptin resistance and energy imbalance. Targeting this stress offers a promising therapeutic strategy for obesity treatment and prevention.

Area of Science:

  • Metabolic disease research
  • Neuroendocrinology
  • Cellular stress response

Background:

  • Obesity is a global epidemic and a significant risk factor for metabolic diseases.
  • Current obesity treatments are limited, necessitating research into underlying mechanisms and novel therapeutic targets.
  • Obesity is associated with endoplasmic reticulum stress and unfolded protein response in metabolic tissues, contributing to insulin/leptin resistance and inflammation.

Purpose of the Study:

  • To review the relationship between hypothalamic endoplasmic reticulum stress and obesity.
  • To elucidate the mechanisms linking hypothalamic endoplasmic reticulum stress to leptin resistance and energy imbalance.
  • To explore therapeutic strategies targeting hypothalamic endoplasmic reticulum stress for obesity treatment.

Main Methods:

  • Literature review of studies investigating endoplasmic reticulum stress in obesity.
  • Analysis of the role of hypothalamic endoplasmic reticulum stress in leptin resistance.
  • Examination of energy homeostasis disruption associated with endoplasmic reticulum stress.

Main Results:

  • Hypothalamic endoplasmic reticulum stress is a central mechanism in obesity-related leptin resistance.
  • Endoplasmic reticulum stress contributes to disrupted energy homeostasis and inflammation in obesity.
  • Targeting endoplasmic reticulum stress may improve leptin sensitivity and energy expenditure.

Conclusions:

  • Hypothalamic endoplasmic reticulum stress plays a critical role in obesity pathogenesis.
  • Strategies targeting endoplasmic reticulum stress present a promising therapeutic avenue for combating obesity.
  • Further research into these mechanisms could lead to effective obesity treatments.
Keywords:
Obesityendoplasmic reticulum stressenergy balanceleptin resistance

More Related Videos

Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells16:43

Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells

Published on: February 18, 2014

13.7K
Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells10:24

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells

Published on: December 17, 2012

14.7K

Related Concept Videos

Endoplasmic Reticulum01:39

Endoplasmic Reticulum

The Endoplasmic Reticulum (ER) in eukaryotic cells is a substantial network of interconnected membranes with diverse functions, from calcium storage to biomolecule synthesis. A primary component of the endomembrane system, the ER manufactures phospholipids critical for membrane function throughout the cell. Additionally, the two distinct regions of the ER specialize in the manufacture of specific lipids and proteins.
111.1K
The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
21.8K
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
8.2K
Directing Proteins to the Rough Endoplasmic Reticulum01:34

Directing Proteins to the Rough Endoplasmic Reticulum

The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
17.9K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.6K
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K