Related Experiment Video
Updated: Feb 13, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis
1Department of Stomatology, the First Hospital of Hohhot, Hohhot, Inner Mongolia, 010030, China. mongzhs77@126.com.
Background:
Studies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore the relationship of COX2 -765G/C polymorphism on periodontitis risk among Chinese population.
Methods:
The databases of PubMed, Springer Link, Ovid, Chinese Wanfang Databases, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine were searched up to January 2017. The overall result and subgroup analysis results were combined using fixed-effect or random-effect based on the heterogeneity.
Results:
Finally, 7 case-control publications including 1399 periodontitis cases and 1663 controls were identified according to the inclusion criteria. In the total analyses, COX2 -765G/C polymorphism had nonsignificant association on periodontitis risk in all models. The subgroup analyses suggested a significantly increased risk of periodontitis in studies with population-based controls and a significantly decreased risk in studies with hospital-based controls.
Conclusions:
This meta-analysis indicated that COX2 -765G/C polymorphism had significantly affect on periodontitis risk among Chinese individuals, which should be confirmed by other ethnic groups.
More Related Videos
Related Concept Videos
Analysis of Population Pharmacokinetic Data
Conservation of Small Populations
What is Population Genetics?
Population Growth
Directing Effect of Substituents: meta-Directing Groups
Single Nucleotide Polymorphisms-SNPs

