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Decaffeinated coffee improves insulin sensitivity in healthy men
Caio E G Reis1, Cicília L R Dos S Paiva2, Angélica A Amato3
11Department of Nutrition,University of Brasilia,Brasília, 70910-900,Brazil.
The British Journal of Nutrition
|March 9, 2018
Summary
Decaffeinated coffee consumption enhances insulin sensitivity in healthy men. Regular coffee, with or without sugar, did not significantly impact glucose metabolism or incretin hormones in this study.
Area of Science:
- Metabolic Health
- Endocrinology
- Nutritional Science
Background:
- Epidemiological studies suggest coffee consumption is linked to reduced type 2 diabetes risk.
- The precise biological mechanisms underlying this association remain largely undetermined.
- Investigating coffee's impact on glucose metabolism and hormonal responses is crucial.
Purpose of the Study:
- To examine the acute effects of decaffeinated, regular, and sweetened regular coffee on glucose metabolism and incretin hormone secretion.
- To compare these effects against control beverages (water with and without sugar).
- To elucidate potential mechanisms linking coffee intake to improved metabolic health.
Main Methods:
- A randomized, single-blind, cross-over study involving 17 healthy male participants.
- Consumption of various coffee types (decaffeinated, regular, regular with sugar) and control beverages.
- Oral glucose tolerance test combined with intravenous [1-13C]glucose administration and stable isotope modeling.
Main Results:
- Decaffeinated coffee significantly improved insulin sensitivity compared to water (P<0.05).
- Regular coffee with sugar showed no significant adverse effects on glucose homeostasis or incretin hormones versus sweetened water.
- No statistically significant differences in glucose, insulin, C-peptide, GIP, or GLP-1 levels were observed between regular/decaffeinated coffee and water.
Conclusions:
- Decaffeinated coffee consumption demonstrably enhances insulin sensitivity in healthy individuals.
- The study found no short-term adverse effects on glucose homeostasis from regular coffee with sugar.
- Incretin hormone levels (GIP and GLP-1) were not significantly altered by any coffee intervention.
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