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Related Experiment Video

Updated: Feb 13, 2026

Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
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[Japan Marrow Donor Program and its coordinating process: current situations].

Tsuneaki Hirakawa1,2, Saiko Kurosawa1, Kinuko Tajima1

  • 1Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|March 9, 2018
PubMed
Summary
This summary is machine-generated.

Donor coordination for unrelated bone marrow transplantation (UBMT) in Japan shows that more matched donors shorten transplant times. Donor age and sex influence coordination success, with younger males more likely to withdraw due to inconvenience.

Keywords:
Donor coordinationJapan Marrow Donor ProgramStem cell transplantation

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Area of Science:

  • Hematology
  • Transplantation Immunology
  • Public Health

Background:

  • The Japan Marrow Donor Program (JMDP) facilitates unrelated bone marrow transplantation (UBMT).
  • Optimizing the donor coordination process is crucial for timely stem cell transplantation.
  • Understanding factors influencing coordination success and failure is essential for program improvement.

Purpose of the Study:

  • To analyze donor coordination efficiency within the JMDP.
  • To identify factors affecting the probability and duration of UBMT.
  • To investigate reasons for donor coordination termination and their relation to donor demographics.

Main Methods:

  • Retrospective analysis of 18,487 patients and 223,842 donor coordination cases from January 2004 to December 2013.
  • Evaluation of factors influencing UBMT probability, including human leukocyte antigen (HLA) matching.
  • Analysis of donor demographics (age, sex) and reasons for coordination termination.

Main Results:

  • Median coordination and days from registration to transplantation for UBMT were 11 and 146 days, respectively.
  • 40% of enrolled patients did not undergo UBMT.
  • Increased HLA 6/6-matched donors correlated with higher UBMT probability and shorter coordination duration.
  • Donor age and sex impacted termination reasons: younger males had lower withdrawal rates due to health but higher rates due to inconvenience.
  • Donors with prior patient-attributed coordination cancellations had higher subsequent donation rates.

Conclusions:

  • Improving HLA matching and donor pool diversity can enhance UBMT rates and reduce waiting times.
  • Targeted strategies addressing donor convenience and health concerns, particularly for younger male donors, may improve retention.
  • Understanding patient-related factors in prior cancellations can inform future donor engagement and increase donation likelihood.