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Computational study on formation of 15-membered azalactone by double reductive amination using molecular mechanics
Hiroaki Gouda1, Naofumi Nakayama2, Tomoaki Miura3,4
1School of Pharmacy, Showa University, Shinagawa, Tokyo, Japan.
Abstract:
Formation of 15-membered azalactone by double reductive amination was analyzed using molecular mechanics and density functional theory calculations for simplified model compounds. As a result, the following aspects were clarified. When methylamine attacks a linear bis-aldehyde in the first step, there are possibilities that two regioisomers are formed. However, one of them exhibited remarkably stable energy level compared with the other. The stable isomer indicated a short distance between a methylamine moiety and an unreacted aldehyde. This short distance, about 2.3 Å, could be explained by hydrogen bonding, which implied relatively easy cyclization in the second step. Moreover, this cyclization process was supposed to be exothermic according to comparison of energy levels before and after cyclization.
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