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Updated: Feb 13, 2026
09:14
Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
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Biocatalytic hydrogen-borrowing cascades.
Tanja Knaus1, Francesco G Mutti1
1Van 't Hoff Institute for Molecular Sciences, HIMS-Biocat, University of Amsterdam, Amsterdam, The Netherlands.
Chimica Oggi
|March 9, 2018
Summary
Enzymatic hydrogen-borrowing cascades offer efficient, one-pot multi-step synthesis by recycling redox equivalents. This approach enhances atom-efficiency and minimizes waste in organic synthesis.
Area of Science:
- Biocatalysis and Organic Synthesis
Background:
- Enzymes offer exquisite chemoselectivity and compatibility for multi-step reactions.
- One-pot biocatalytic reactions have gained prominence in the last decade.
- Hydrogen-borrowing cascades are a key strategy for enhancing efficiency.
Purpose of the Study:
- To review the current state-of-the-art in biocatalytic hydrogen-borrowing cascades.
- To highlight the advantages of these cascades in organic synthesis.
- To provide future perspectives for their broader application.
Main Methods:
- Literature review of biocatalytic hydrogen-borrowing cascades.
- Analysis of enzyme compatibility and chemoselectivity in cascade reactions.
- Discussion of atom-efficiency and redox equivalent recycling.
Main Results:
- Biocatalytic hydrogen-borrowing cascades maximize atom-efficiency.
- Internal recycling of redox equivalents eliminates the need for external oxidants/reductants.
- These cascades enable efficient multi-step syntheses in one-pot.
Conclusions:
- Biocatalytic hydrogen-borrowing cascades represent a powerful tool for sustainable organic synthesis.
- Further implementation of these cascades can significantly advance synthetic chemistry.
- The field shows great promise for wider adoption in chemical manufacturing.
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