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[Immune complex formation and complement changes in osteosarcoma patients treated with high-dose methotrexate].

D Körholz, U Körholz, H Jürgens

Klinische Padiatrie

|January 1, 1987

Summary

Elevated immune complexes in osteosarcoma patients correlate with disease activity. Methotrexate (MTX) treatment did not directly influence immune complex formation or complement system changes in children studied.

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Pediatric blood & cancer·2018

Area of Science:

Immunology
Oncology
Pharmacology

Context:

Osteosarcoma patients often exhibit elevated immune complex levels linked to disease progression.
High-dose methotrexate (MTX) therapy can induce specific MTX-containing immune complexes, leading to anaphylaxis in some patients.
Understanding the role of immune complexes during MTX treatment is crucial for managing osteosarcoma.

Purpose:

To investigate the impact of MTX on immune complex formation and complement system activation in pediatric osteosarcoma patients.
To analyze the presence of polyethyleneglycol (PEG)-precipitable and C3b-binding immune complexes during MTX chemotherapy.
To assess the prognostic value of immune complexes and complement changes in osteosarcoma.

Summary:

This study examined immune complexes and complement factors in 10 children with osteosarcoma undergoing MTX treatment (COSS 80 protocol).

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No direct correlation was found between MTX infusion and the formation of PEG-precipitable or C3b-binding immune complexes, nor were significant changes in the complement system observed.

Elevated immune complexes at the end of chemotherapy were associated with a poorer prognosis, but complement analysis showed no prognostic value.

Impact:

Findings suggest MTX itself does not directly drive immune complex formation in this cohort.
Elevated immune complexes post-chemotherapy may serve as a negative prognostic indicator in osteosarcoma.
Further research is needed to elucidate the precise mechanisms and clinical implications of immune complex dynamics in osteosarcoma treatment.