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Correlation Between Subclinical Hypothyroidism and Dyslipidemia
Alireza Rastgooye Haghi1, Mahdis Solhjoo1, Mohammad Hossein Tavakoli1
1Dept. of Medical Science of Hamadan University of Medical sciences, Hamedan, Iran.
Iranian Journal of Pathology
|March 9, 2018
Summary
Subclinical hypothyroidism (SCH) is linked to unhealthy lipid profiles, specifically higher LDL and lower HDL cholesterol. This suggests screening for thyroid issues in patients with dyslipidemia is important.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Clinical Biochemistry
Background:
- Thyroid hormones regulate lipid metabolism.
- Subclinical hypothyroidism (SCH) involves elevated thyroid-stimulating hormone (TSH) with normal thyroxine (T4).
- SCH may be associated with dyslipidemia.
Purpose of the Study:
- To assess the association between subclinical hypothyroidism and lipid profile changes.
- Investigate the relationship between SCH and lipid abnormalities.
Main Methods:
- Compared 53 SCH patients with 53 euthyroid controls (aged 18-60).
- Matched groups by gender, age, and BMI.
- Measured total serum cholesterol, HDL, LDL, and triglycerides.
Main Results:
- SCH patients had significantly higher LDL and lower HDL cholesterol (P<0.001).
- No significant differences in triglycerides or total cholesterol.
- Dyslipidemia prevalence was significant in females with SCH (P=0.009).
- Overall correlation between dyslipidemia and SCH found (P=0.04).
Conclusions:
- Subclinical hypothyroidism is associated with dyslipidemia.
- Biochemical screening for thyroid dysfunction is recommended for patients with dyslipidemia.
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