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Updated: Feb 13, 2026

Simple, Affordable, and Modular Patterning of Cells using DNA
Published on: February 24, 2021
Photothermal fabrication of microscale patterned DNA hydrogels
Suguru Shimomura1, Takahiro Nishimura1, Yusuke Ogura1
1Graduate School of Information Science and Technology, Osaka University, Suita, Osaka, Japan.
Abstract:
This paper introduces a method for fabricating microscale DNA hydrogels using irradiation with patterned light. Optical fabrication allows for the flexible and tunable formation of DNA hydrogels without changing the environmental conditions. Our scheme is based on local heat generation via the photothermal effect, which is induced by light irradiation on a quenching species. We demonstrate experimentally that, depending on the power and irradiation time, light irradiation enables the creation of local microscale DNA hydrogels, while the shapes of the DNA hydrogels are controlled by the irradiation patterns.
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