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Systemic Treatment for Adults with Synovial Sarcoma
Ingrid M E Desar1, Emmy D G Fleuren2, Winette T A van der Graaf3,4
1Department of Medical Oncology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands.
Current Treatment Options in Oncology
|March 9, 2018
Summary
Systemic chemotherapy, particularly ifosfamide combinations, shows activity in treating synovial sarcoma (SS), a rare soft tissue sarcoma (STS). New treatments targeting metastatic SS are under investigation.
Area of Science:
- Oncology
- Medical Research
- Pharmacology
Background:
- Synovial sarcoma (SS) is a rare and highly malignant soft tissue sarcoma (STS).
- Survival rates for SS have seen limited improvement over recent years.
- This review focuses on systemic treatment strategies for adult SS patients.
Purpose of the Study:
- To review the current landscape of systemic treatments for adult synovial sarcoma.
- To highlight the efficacy of chemotherapy regimens, particularly ifosfamide-based treatments.
- To discuss emerging therapeutic approaches for metastatic SS.
Main Methods:
- Literature review focusing on systemic therapies for synovial sarcoma.
- Analysis of clinical trial data and published studies on chemotherapy and targeted agents.
- Evaluation of treatment outcomes in different lines of therapy for SS.
Main Results:
- Synovial sarcoma is relatively chemosensitive compared to other STS.
- Ifosfamide and its combinations demonstrate activity in various treatment lines.
- Neoadjuvant doxorubicin and ifosfamide show promise in high-risk STS, potentially improving outcomes.
- Pazopanib and trabectedin are active in second and later lines of treatment for metastatic SS.
Conclusions:
- Ifosfamide-based chemotherapy remains a cornerstone in SS treatment.
- Combination chemotherapy with doxorubicin and ifosfamide may improve outcomes in specific settings.
- Numerous novel therapeutic strategies, including targeted therapies and immunotherapy, are under investigation for metastatic SS.
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