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[Autistic regression: clinical and aetiological aspects].

V L Ruggieri1, C L Arberas2

  • 1Hospital Nacional de Pediatria - Prof. Dr. J.P. Garrahan, Buenos Aires, Argentina.

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Autistic regression, a loss of skills in children with autism spectrum disorder, requires careful evaluation. Identifying the cause is crucial for targeted treatment and genetic counseling.

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Area of Science:

  • Neurodevelopmental disorders
  • Pediatric neurology

Background:

  • Autism spectrum disorders (ASD) involve social, communication, and behavioral challenges.
  • Approximately 30% of children with ASD experience regression, a loss of acquired skills.
  • Autistic regression can stem from various underlying conditions, not always being a typical ASD manifestation.

Purpose of the Study:

  • To analyze conditions associated with autistic regression in children.
  • To investigate genetic, toxic, autoimmune, nutritional, and epileptic causes.

Main Methods:

  • Review of distinct conditions contributing to autistic regression.
  • Analysis of potential etiological factors.

Main Results:

  • Autistic regression necessitates a hierarchical approach to identify diverse causes.
  • Potential etiologies include genetic factors, toxins, autoimmune processes, nutritional deficiencies, and epilepsy.

Conclusions:

  • Identifying the etiology of autistic regression is essential for effective management.
  • Specific treatments and genetic counseling can be initiated once the cause is determined.