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Overview of the Baculovirus Expression System.

Adam C Chambers1, Mine Aksular1, Leo P Graves2

  • 1Oxford Expression Technologies Ltd, Gipsy Lane, Oxford, United Kingdom.

Current Protocols in Protein Science
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PubMed
Summary

Insect baculoviruses are engineered as expression vectors for recombinant proteins. Advances in the baculovirus expression vector system (BEVS) enable efficient protein production and gene delivery into mammalian cells.

Keywords:
BEVSBacMambaculovirus expression vectorinsect cells

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Area of Science:

  • Molecular Biology
  • Virology
  • Biotechnology

Background:

  • Baculoviruses are double-stranded DNA insect viruses.
  • They possess a unique biphasic replication cycle within insect hosts.
  • This replication strategy is key to their adaptation as expression vectors.

Purpose of the Study:

  • To explain the insect baculovirus replication cycle.
  • To detail the development and advancements of the baculovirus expression vector system (BEVS).
  • To highlight the applications of baculovirus vectors in protein production and gene delivery.

Main Methods:

  • Review of baculovirus structure and replication.
  • Historical overview of BEVS development from the 1980s to present.
  • Description of advancements in recombinant virus production and protein yield optimization.

Main Results:

  • BEVS is an established tool for producing recombinant proteins, protein complexes, and virus-like particles.
  • Recent advances facilitate rapid recombinant virus generation and enhanced protein yields.
  • Recombinant BacMam vectors show promise for gene delivery in mammalian and human cells.

Conclusions:

  • The baculovirus expression vector system is a versatile platform for recombinant protein production.
  • Ongoing developments continue to improve the efficiency and applicability of BEVS.
  • Baculovirus-derived vectors have expanded applications, including gene therapy in mammalian systems.