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Updated: Feb 13, 2026
Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Synthesis of 2,6,7-Trisubstituted Prenylated indole
Motoki Shiozawa1, Keisuke Iida2, Minami Odagi1
1Department of Biotechnology and Life Science, Graduate Scholl of Technology , Tokyo University of Agriculture and Technology , 2-24-16, Naka-cho , Koganei City 184-8588 , Tokyo , Japan.
Abstract:
Prenylated indole alkaloids bearing more than one prenyl or reverse-prenyl group show various biological activities. Among them, synthesis of trisubstituted-type prenylated indoles have not been well explored because of the difficulty in regioselective introduction of multiple prenyl and reverse-prenyl groups due to steric hindrance problems. Herein, we describe a synthesis of 2,6,7-trisubstituted prenylated indole using aza-Claisen rearrangement under mild conditions to introduce a prenyl group at C7 in the presence of the prenyl group at C6.
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