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Related Experiment Videos

Sleeping Sickness in the 'Omics Era.

Natalia Tiberti1, Jean-Charles Sanchez1

  • 1Translational Biomarker Group, University of Geneva, Geneva, Switzerland.

Proteomics. Clinical Applications
|March 9, 2018
PubMed
Summary
This summary is machine-generated.

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Omics studies reveal new insights into the parasite Trypanosoma brucei, aiding efforts to combat sleeping sickness (human African trypanosomiasis). These findings offer potential disease markers and therapeutic targets for this neglected tropical disease.

Area of Science:

  • Neglected tropical diseases
  • Parasitology
  • Genomics and Proteomics

Background:

  • Sleeping sickness, caused by Trypanosoma brucei, disproportionately affects impoverished sub-Saharan African communities.
  • Significant progress in reducing human African trypanosomiasis (HAT) incidence has been achieved through coordinated efforts in screening, vector control, and improved treatments.
  • The World Health Organization aimed for HAT elimination as a public health concern by 2020.

Purpose of the Study:

  • To review the impact of 'omics studies on understanding sleeping sickness.
  • To highlight novel parasite properties and host-parasite interactions revealed by 'omics data.
  • To identify potential biomarkers and therapeutic targets for HAT.

Main Methods:

  • Comprehensive literature review of 'omics studies related to Trypanosoma brucei.
Keywords:
BiomarkersParasite biologySleeping sicknessTrypanosoma brucei‘Omics

Related Experiment Videos

  • Analysis of findings concerning parasite biology, subcellular organelles, and host responses.
  • Synthesis of data to identify potential diagnostic and therapeutic avenues.

    • Main Results:

    • 'Omics approaches have uncovered new characteristics of Trypanosoma brucei's subcellular organelles.
    • Significant alterations in the host during infection have been elucidated.
    • 'Omics data suggest potential novel disease markers and therapeutic targets.

    Conclusions:

    • 'Omics studies are crucial for advancing the understanding and control of sleeping sickness.
    • These studies provide a foundation for developing new strategies for HAT diagnosis and treatment.
    • Continued 'omics research is vital for achieving the goal of HAT elimination.