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Updated: Feb 13, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
YB-1 promotes laryngeal squamous cell carcinoma progression by inducing miR-155 expression via c-Myb
Xudong Zhao1, Wei Zhang2, Wenyue Ji1
1Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, PR China.
Aim:
In this study, we investigated the role of Y-box binding protein-1 (YB-1), c-Myb and miR-155 in human laryngeal squamous cell carcinoma (LSCC) progression.
Materials & Methods:
Quantitative real-time PCR, western blot, MTT and Transwell were conducted to determine the expression and function of YB-1/miR-155 pathway. Univariate and multivariate analyses were used to determine the prognostic factors.
Results:
Expression of YB-1, c-Myb and miR-155 was higher in LSCC tissues. YB-1 promoted proliferation, invasiveness and migration of Hep-2 cells in vitro. Patients with higher YB-1 correlated with advanced T stage, poor differentiation and cervical metastasis. LSCC patients with high YB-1 expression showed poor overall survival.
Conclusion:
YB-1 promotes LSCC progression by increasing miR-155 levels via c-Myb and acts as a prognostic factor.
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