Related Experiment Video

Updated: Feb 13, 2026

Measuring the 50% Haemolytic Complement CH50 Activity of Serum
08:26

Measuring the 50% Haemolytic Complement CH50 Activity of Serum

Published on: March 29, 2010

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Evolving complexity of complement-related diseases: C3 glomerulopathy and atypical haemolytic uremic syndrome

H Terence Cook1

  • 1Department of Medicine, Imperial College London, London, UK.

Current Opinion in Nephrology and Hypertension
|March 9, 2018
PubMed

Insights

Recent advances clarify the pathology of C3 glomerulopathy and atypical haemolytic uremic syndrome (aHUS), revealing complement alternative pathway dysregulation. New insights suggest therapeutic targets for these kidney diseases.

Area of Science:

  • Nephrology
  • Immunology
  • Complement System Biology

Background:

  • C3 glomerulopathy and atypical haemolytic uremic syndrome (aHUS) are kidney diseases linked to complement alternative pathway dysregulation.
  • Understanding their pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To review recent advances in the pathology of C3 glomerulopathy and aHUS.
  • To explore new insights into classification and pathogenesis.
  • To highlight emerging therapeutic strategies targeting the complement cascade.

Main Methods:

  • Literature review of recent articles on C3 glomerulopathy and aHUS.
  • Analysis of new findings on complement pathway abnormalities.
  • Synthesis of evidence regarding monoclonal gammopathy and treatment.

Main Results:

  • New insights into C3 glomerulopathy classification and its relationship with immune complex-mediated glomerulonephritis.
  • Evidence for overlap in pathogenesis between C3 glomerulopathy and aHUS.
  • Growing evidence linking monoclonal gammopathy to C3 glomerulopathy/aHUS in older patients, with potential for treatment of the plasma cell clone to improve kidney outcomes.

Conclusions:

  • Recent research has significantly advanced the understanding of C3 glomerulopathy and aHUS.
  • Complement dysregulation is a key factor, with novel therapeutic agents emerging.
  • Monoclonal gammopathy represents an important treatable cause in specific patient populations.
Abstract

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