Related Experiment Video
Updated: Feb 13, 2026
09:15
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
1.3K
Left Ventricular Assist Device Thrombosis-Amiodarone-Induced Hyperthyroidism: Causal Link?
Indranee Rajapreyar1, Deepak Acharya1, José Tallaj1
1From the Department of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|March 9, 2018
Summary
Ventricular arrhythmias are common in left ventricular assist device (LVAD) patients. Amiodarone-induced hyperthyroidism can lead to LVAD thrombosis due to a hypercoagulable state.
Area of Science:
- Cardiology
- Endocrinology
- Medical Devices
Background:
- Ventricular arrhythmias (VAs) affect 20-50% of patients with left ventricular assist devices (LVADs).
- While VAs are often tolerated with LVAD support, long-term effects can include impaired right ventricular function.
- Current management strategies for VAs in LVAD patients involve antiarrhythmic drugs or ablation.
Observation:
- Amiodarone is a common first-line antiarrhythmic agent post-LVAD implantation.
- Chronic amiodarone use can induce thyroid dysfunction (hyperthyroidism or hypothyroidism) in 5-10% of patients.
- Hyperthyroidism is associated with endothelial dysfunction and altered coagulation/fibrinolytic pathways, promoting a hypercoagulable state.
Findings:
- This report details two cases of left ventricular assist device (LVAD) thrombosis.
- LVAD thrombosis in these cases was potentiated by amiodarone-induced hyperthyroidism (AIT).
- The study discusses the pathophysiological mechanisms linking AIT to a hypercoagulable state.
Implications:
- Amiodarone-induced hyperthyroidism is a potential risk factor for LVAD thrombosis.
- Clinicians should monitor thyroid function in LVAD patients on chronic amiodarone therapy.
- Understanding the hypercoagulable mechanisms associated with AIT is crucial for managing LVAD patients.
Related Concept Videos
01:21Causality in Epidemiology
1.7K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.7K
01:30Venous Thrombosis I: Introduction
489
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
489
02:04Covalently Linked Protein Regulators
9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
9.7K
01:19X-linked Traits
58.9K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.9K
01:28Criteria for Causality: Bradford Hill Criteria - II
1.3K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.3K
01:30Criteria for Causality: Bradford Hill Criteria - I
1.2K
The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
1.2K