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Updated: Feb 13, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
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LONGITUDINAL CHANGES IN CHOROIDAL AND RETINAL THICKNESSES IN CHILDREN WITH MYOPIC SHIFT

Peiyao Jin1,2, Haidong Zou1,2, Xun Xu1,2

  • 1Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.

Retina (Philadelphia, Pa.)
|March 9, 2018
PubMed

Insights

Children

Area of Science:

  • Ophthalmology
  • Pediatric Eye Health

Background:

  • Myopic shift is a growing concern in pediatric populations.
  • Understanding retinal and choroidal development is crucial for myopia management.

Purpose of the Study:

  • To investigate choroidal and retinal development in children.
  • To analyze changes during myopic shift in pediatric subjects.

Main Methods:

  • Longitudinal study of 118 children (7-12 years) over 1 year.
  • Utilized cycloplegic refraction, axial length measurement, and swept-source OCT.
  • Compared choroidal and retinal thickness changes in children with and without myopic shift.

Main Results:

  • 74.6% of children experienced myopic shift.
  • Significant central foveal choroidal thinning observed in those with myopic shift (P < 0.01).
  • Axial length increase and choroidal thinning were independently associated with myopic shift.

Conclusions:

  • Choroidal thinning is an early indicator of myopic progression in children.
  • Axial elongation and choroidal thinning are key factors in pediatric myopic shift.
Abstract

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