Effectiveness of revascularization interventions compared with medical therapy in patients with ischemic

Aziz Rezapour1, Saeed Bagheri Faradonbeh, Vahid Alipour

  • 1Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Health Economics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Medicine
|March 9, 2018
PubMed

Insights

This systematic review compares revascularization interventions with medical therapy for ischemic cardiomyopathy. It aims to inform treatment decisions for patients and healthcare providers.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Interventional Cardiology

Background:

  • Cardiomyopathies affect heart muscle; ischemic cardiomyopathy stems from vascular disorders.
  • Diagnosis often requires angiography.
  • Treatment options include medical therapy, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG).

Purpose of the Study:

  • To systematically review and evaluate the effectiveness of revascularization interventions versus medical therapy in patients with ischemic cardiomyopathy.
  • To provide evidence-based insights for clinical decision-making.

Main Methods:

  • Systematic review of observational and interventional studies (English and Persian).
  • Exclusion of animal studies.
  • Comprehensive electronic database searches (PubMed, Cochrane, Scopus, Web of Science, EMBASE, etc.) and grey literature.
  • Meta-analysis using Comprehensive Meta-Analysis (CMA) software for integrating similar results.
  • Reporting of results using relative risk with 95% confidence intervals.

Main Results:

  • Results will be published in a peer-reviewed journal.

Conclusions:

  • This review is the first to compare revascularization interventions with medical therapy for ischemic cardiomyopathy.
  • Findings will benefit patients, healthcare providers, and policymakers in managing ischemic cardiomyopathy.
Abstract

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
591
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
530
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
593
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
241
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K