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Effectiveness of revascularization interventions compared with medical therapy in patients with ischemic
Aziz Rezapour1, Saeed Bagheri Faradonbeh, Vahid Alipour
1Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Health Economics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Insights
This systematic review compares revascularization interventions with medical therapy for ischemic cardiomyopathy. It aims to inform treatment decisions for patients and healthcare providers.
Area of Science:
- Cardiology
- Vascular Medicine
- Interventional Cardiology
Background:
- Cardiomyopathies affect heart muscle; ischemic cardiomyopathy stems from vascular disorders.
- Diagnosis often requires angiography.
- Treatment options include medical therapy, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG).
Purpose of the Study:
- To systematically review and evaluate the effectiveness of revascularization interventions versus medical therapy in patients with ischemic cardiomyopathy.
- To provide evidence-based insights for clinical decision-making.
Main Methods:
- Systematic review of observational and interventional studies (English and Persian).
- Exclusion of animal studies.
- Comprehensive electronic database searches (PubMed, Cochrane, Scopus, Web of Science, EMBASE, etc.) and grey literature.
- Meta-analysis using Comprehensive Meta-Analysis (CMA) software for integrating similar results.
- Reporting of results using relative risk with 95% confidence intervals.
Main Results:
- Results will be published in a peer-reviewed journal.
Conclusions:
- This review is the first to compare revascularization interventions with medical therapy for ischemic cardiomyopathy.
- Findings will benefit patients, healthcare providers, and policymakers in managing ischemic cardiomyopathy.
Background:
Cardiomyopathies is a group of heart diseases that directly affects the heart muscle, and their causes is not just high blood pressure, congenital and pericardial diseases but ischemic cardiomyopathy disease are also caused by vascular disorders, and to confirm the diagnosis, angiography is required. There are several methods for treating and controlling ischemic cardiomyopathy in world health systems and especially in the Iran health system, which include medical treatment, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG).
Methods:
This systematic review will includes observational and interventional studies in English and Persian languages and evaluates effectiveness of revascularization interventions and medical therapy in patients with ischemic cardiomyopathy. Animal studies will not be considered. In this systematic review, our sources of information will be electronic databases, trial registries, and different types of grey literature. An electronic search is performed through PubMed, Cochrane library, Scopus, Web of Science, EMBASE, Tufts Medical Center Cost-Effectiveness Analysis Registry, NHS Economic Evaluations Database. To integrate the results of studies with similar results, meta-analysis will be used, for which Comprehensive Meta-Analysis (CMA) software will be used. Results are provided using relative risk with a 95% confidence interval for information.
Results:
The results of this systematic review will be published in a peer-reviewed journal.
Conclusion:
To our knowledge, this systematic review will be the first to evaluate existing research on the effectiveness of revascularization interventions compared with medical therapy in patients with ischemic cardiomyopathy. The review will benefit patients, healthcare providers, and policymakers.
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