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Updated: Feb 13, 2026

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry
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Assessing protein-ligand interaction scoring functions with the CASF-2013 benchmark

Yan Li1, Minyi Su1, Zhihai Liu1

  • 1State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

Nature Protocols
|March 9, 2018
PubMed
Summary

The Comparative Assessment of Scoring Functions (CASF) benchmark provides an objective evaluation of computational scoring functions for drug design. CASF-2013 offers a standardized method to assess scoring, ranking, docking, and screening powers of these essential tools.

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