Related Experiment Video

Updated: Feb 13, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K

Stimuli-Responsive NO Release for On-Demand Gas-Sensitized Synergistic Cancer Therapy

Wenpei Fan1, Bryant C Yung1, Xiaoyuan Chen1

  • 1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.

Angewandte Chemie (International Ed. in English)
|March 9, 2018
PubMed

Insights

Gas therapy utilizes nitric oxide (NO) for cancer treatment, either directly killing cells or enhancing other therapies. This review covers stimuli-responsive NO-releasing nanomedicines for synergistic cancer therapy.

Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Cancer Therapy

Background:

  • Gas therapy, particularly using nitric oxide (NO), is a rapidly growing field due to its biocompatibility.
  • Nitric oxide (NO) exhibits dual roles in cancer treatment: direct cytotoxicity at high concentrations and sensitization of cancer cells for synergistic therapy.

Purpose of the Study:

  • To review the chemical design and biomedical applications of stimuli-responsive NO-releasing nanomedicines.
  • To discuss the use of these nanomedicines for on-demand, NO-sensitized synergistic cancer therapy.

Main Methods:

  • Review of recent state-of-the-art studies on NO-releasing nanomedicines.
  • Analysis of endogenous/exogenous stimuli-responsive designs.
  • Discussion of biomedical applications in synergistic cancer therapy.

Main Results:

  • Emerging nanomedicines offer on-demand NO release for targeted cancer therapy.
  • Stimuli-responsive designs enhance the efficacy of NO-based synergistic treatments.
  • Significant advancements in chemical design for biomedical applications.

Conclusions:

  • NO-releasing nanomedicines represent a promising frontier in synergistic cancer therapy.
  • Further research into potential challenges is needed to advance NO gas therapy.
  • Development of novel NO nanomedicines can lead to new therapeutic strategies.
Keywords:
controlled releasedrug deliverygas therapynitric oxidesynergistic therapy

More Related Videos

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.0K
Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.5K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
2
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Gas Exchange and Transport01:20

Gas Exchange and Transport

Gas exchange, the intake of molecular oxygen (O2) from the environment and the outflow of carbon dioxide (CO2) into the environment, is necessary for cellular function. Gas exchange during respiration occurs largely via the movement of gas molecules along pressure gradients. Gas travels from areas of higher partial pressure to areas of lower partial pressure. In mammals, gas exchange occurs in the alveoli of the lungs, which are adjacent to capillaries and share a membrane with them.
77.2K
Responses to Drought and Flooding02:41

Responses to Drought and Flooding

Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.
12.1K
Kinetic Molecular Theory and Gas Laws Explain Properties of Gas Molecules02:34

Kinetic Molecular Theory and Gas Laws Explain Properties of Gas Molecules

The test of the kinetic molecular theory (KMT) and its postulates is its ability to explain and describe the behavior of a gas. The various gas laws (Boyle’s, Charles’s, Gay-Lussac’s, Avogadro’s, and Dalton’s laws) can be derived from the assumptions of the KMT, which have led chemists to believe that the assumptions of the theory accurately represent the properties of gas molecules.
37.6K