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Toxicity Testing in Animals01:23

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
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Construction and Testing of Coin Cells of Lithium Ion Batteries
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[Lithium toxicity after bariatric surgery].

R Niessen1, T Sottiaux1, A Schillaci2

  • 1Service des Soins Intensifs, Clinique Notre-Dame de Grâce, Gosselies, Belgique.

Revue Medicale De Liege
|March 9, 2018
PubMed
Summary
This summary is machine-generated.

Bariatric surgery patients on lithium may face toxicity due to physiological changes. Closer monitoring of lithium levels post-surgery is crucial for patient safety.

Keywords:
Lithium toxicitySleeve gastrectomyBariatric surgery

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Area of Science:

  • Nephrology
  • Psychiatry
  • Bariatric Surgery

Background:

  • Established correlation between neuropsychiatric disorders and obesity.
  • 1.2-4% of bariatric surgery patients use lithium for bipolar disorder.
  • Bariatric surgery can alter drug pharmacokinetics.

Observation:

  • A 40-year-old female experienced lithium toxicity post-vertical sleeve gastrectomy.
  • The patient presented with severe neurological and renal symptoms.
  • Intensive care unit admission and hemodiafiltration were required.

Findings:

  • Physiological and pharmacokinetic shifts post-bariatric surgery can precipitate lithium poisoning.
  • Case highlights the risk of lithium toxicity in this patient population.
  • Literature review supports the link between bariatric procedures and altered lithium metabolism.

Implications:

  • Emphasizes the critical need for vigilant monitoring of serum lithium levels after bariatric surgery.
  • Suggests revised perioperative management strategies for lithium therapy.
  • Aims to improve patient outcomes and prevent adverse events in patients with co-occurring psychiatric and eating disorders.