Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.5K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.5K
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

12.4K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
12.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026
Same author

Reply to "Touchstones of compassionate care in allergy-immunology beyond artificial intelligence: connection and generational legacy".

The journal of allergy and clinical immunology. In practice·2026
Same author

The Role of Maternal Diet and Supplements During Pregnancy and Lactation in the Prevention and Development of Food Allergies and Atopic Dermatitis.

The journal of allergy and clinical immunology. In practice·2026
Same author

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis.

Cell host & microbe·2026
Same author

Modulation of Forward Propulsion and Foot Dorsiflexion by Spinal and Muscular Stimulation During Human Stepping.

Life (Basel, Switzerland)·2026
Same author

Number of food allergies and diet quality.

The journal of allergy and clinical immunology. Global·2026

Related Experiment Video

Updated: Feb 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.5K

The nasal microbiome in asthma.

Mina Fazlollahi1, Tricia D Lee2, Jade Andrade3

  • 1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

The Journal of Allergy and Clinical Immunology
|March 9, 2018
PubMed
Summary

The nasal microbiome differs significantly between individuals with and without asthma, with specific bacterial species linked to asthma activity. These findings suggest potential biomarkers for asthma management.

Keywords:
16S rRNA sequencingNasalasthmamicrobiomeupper airwayupper respiratory tract

More Related Videos

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

11.8K
Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.5K
Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

11.8K
Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.6K

Area of Science:

  • Microbiology
  • Immunology
  • Genomics

Background:

  • The nasal microbiota plays a potential role in the development and progression of asthma.
  • Understanding the nasal microbiome's composition is crucial for elucidating asthma pathobiology.

Purpose of the Study:

  • To characterize and compare the nasal microbiome across individuals with exacerbated asthma, non-exacerbated asthma, and healthy controls.
  • To identify specific nasal microbial taxa associated with asthma activity and severity.

Main Methods:

  • 16S ribosomal RNA sequencing was performed on nasal swabs from 72 participants.
  • Bioinformatic analyses included Quantitative Insights into Microbial (QIIME) and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt).
  • Differential abundance of microbial species and metabolic pathways was assessed using LEfSe, STAMP, and quantitative PCR.

Main Results:

  • Significant differences in nasal bacterial composition were observed among the three groups (P = 2.2 x 10^-2).
  • Subjects with asthma showed enrichment in Bacteroidetes and Proteobacteria phyla compared to controls.
  • Prevotella buccalis and Gardnerella vaginalis were significantly overrepresented in individuals with asthma.

Conclusions:

  • Nasal microbiome composition is distinct in individuals with varying asthma activity.
  • Specific nasal taxa, such as Prevotella buccalis and Gardnerella vaginalis, may serve as potential biomarkers for asthma activity.
  • Further research into the mechanistic roles of these nasal microbes in asthma is warranted.