Related Experiment Video
Updated: Feb 13, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells
Suvi T Häkkinen1, Heli Nygren1, Natalia Maiorova1
1VTT Technical Research Centre of Finland Ltd., Espoo, Finland.
Abstract:
In this study, three semisynthetic betulonic acid-based compounds, 20(29)-dihydrolup-2-en[2,3-d]isoxazol-28-oic acid, 1-betulonoylpyrrolidine, and lupa-2,20(29)-dieno[2,3-b]pyrazin-28-oic acid, were studied in biotransformation experiments using Nicotiana tabacum and Catharanthus roseus cell suspension cultures. Biotransformation was performed using cyclodextrin to aid dissolving poorly water-soluble substrates. Several new derivatives were found, consisting of oxidized and glycosylated (pentose- and hexose-conjugated) products.
Related Concept Videos
Plant Cells and Tissues
Plant Cell Wall
Plant Cell Wall
Drug Biotransformation: Overview
Drug Biotransformation: Overview
Factors Affecting Drug Biotransformation: Biological
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...

