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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Generation of Tissue Spheroids via a 3D Printed Stamp-Like Device
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3D-printed membrane for guided tissue regeneration.

Lobat Tayebi1, Morteza Rasoulianboroujeni2, Keyvan Moharamzadeh3

  • 1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK; Marquette University School of Dentistry, Milwaukee, WI 53233, USA.

Materials Science & Engineering. C, Materials for Biological Applications
|March 10, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a 3D-printed gelatin/elastin/sodium hyaluronate membrane for guided tissue regeneration (GTR). This biocompatible and mechanically stable construct shows promise for GTR applications.

Keywords:
3D-printingGuided tissue regeneration (GTR)MembraneResorbable membraneSoft tissue scaffolds

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Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Three-dimensional (3D) printing is explored for bioengineered tissues and biomedical devices.
  • Guided tissue regeneration (GTR) requires specialized membranes for effective treatment.

Purpose of the Study:

  • To develop and characterize a 3D-printed hybrid construct for potential guided tissue regeneration (GTR) applications.
  • To optimize bioink composition and printing parameters for a functional GTR membrane.

Main Methods:

  • Rheology analyses were performed to select a bioink composed of 8% gelatin, 2% elastin, and 0.5% sodium hyaluronate.
  • A 6-layer membrane was 3D printed with specific strand angles and characterized using 3D Laser Measuring imaging.
  • Mechanical testing (static and dynamic tensile) and in vitro biocompatibility assays (cell seeding, histological analysis, viability assays) were conducted.

Main Results:

  • The selected bioink produced a 150μm thick, flexible membrane with distinct pore sizes on each side.
  • Mechanical testing showed a static tensile modulus of 1.95±0.55MPa and dynamic tensile storage modulus of 314±50kPa.
  • In vitro tests confirmed desirable biocompatibility and barrier function, separating epithelial layers from underlying tissues.

Conclusions:

  • A biocompatible and bio-resorbable 3D-printed gelatin/elastin/sodium hyaluronate membrane was successfully developed and characterized.
  • The membrane exhibits optimal biostability, mechanical strength, and surgical handling properties for GTR procedures.
  • This novel construct holds potential for enhancing guided tissue regeneration outcomes.