In vivo redox changes in some organs in response to Gramoxone

The effects of Gramoxone on the redox state potential (E'0) of the liver, heart, skeletal muscle and lung of guinea-pig were examined at different times. The E'0 values were compared with control measurements. Gramoxone was found to cause mainly a significant E'0 increase with time in lung tissues. This lends support to the general experience that the primary target organ for paraquat (PQ) toxicity is the lung. It is suggested as explanation of the observation that the lung is most actively connected with molecular oxygen.