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Otoacoustic emissions in children treated with gentamicin in a secondary hospital

Jose Miguel Sequi Canet1, Carlos Miguel Angelats Romero1, Jose Miguel Sequi Sabater1

  • 1Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, España.

Acta Otorrinolaringologica Espanola
|March 10, 2018
PubMed

Insights

Gentamicin is safe for children when used for less than 10 days. Evoked otoacoustic emissions (EOAE) effectively monitor for hearing loss from gentamicin ototoxicity.

Area of Science:

  • Pediatrics
  • Otolaryngology
  • Pharmacology

Background:

  • The National Commission for the Early Detection of Hearing Loss (CODEPEH) advises hearing re-evaluation after exposure to ototoxic drugs like gentamicin.
  • Evoked otoacoustic emissions (EOAE) are a valuable tool for assessing cochlear function.

Purpose of the Study:

  • To evaluate the ototoxicity of gentamicin in children.
  • To assess the utility of EOAE in monitoring gentamicin's effects on hearing.

Main Methods:

  • A prospective study involved 92 children treated with intravenous gentamicin.
  • Serial EOAE measurements were taken: on admission, at treatment completion, and one month post-treatment.

Main Results:

  • No children in the study experienced hearing impairment due to gentamicin treatment.
  • The study found no ototoxic effects from gentamicin under the specified conditions.

Conclusions:

  • Gentamicin appears safe for pediatric use in treatments under 10 days at described doses.
  • EOAE provide a reliable, non-invasive method for detecting gentamicin-induced ototoxicity, potentially reducing the need for drug level monitoring.
Abstract

Keywords:
GentamicinGentamicinaHearing lossOtoacoustic emissionsOtoemisiones acústicasOtotoxicidadOtotoxicitySordera

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