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Prenatal Brain MR Imaging: Reference Linear Biometric Centiles between 20 and 24 Gestational Weeks.

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Summary
This summary is machine-generated.

This study provides reference centiles for fetal brain biometry in early second-trimester pregnancies (20-24 weeks gestation) using magnetic resonance imaging (MRI). These findings offer a valuable tool for assessing normal fetal brain development.

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Area of Science:

  • Prenatal imaging
  • Fetal neurodevelopment
  • Medical biometry

Background:

  • Biometric evaluation is crucial in prenatal brain MRI.
  • Existing reference centiles primarily cover late second and third trimesters.
  • Data for early second-trimester fetal brains are lacking.

Purpose of the Study:

  • To establish reference centiles for linear biometric data of fetal brains.
  • To cover the gestational age range of 20 to 24 weeks.
  • To aid in the assessment of early fetal brain development.

Main Methods:

  • Retrospective collection of 169 prenatal brain MRI examinations from singleton pregnancies (20-24 weeks gestation).
  • Inclusion criteria: normal fetal brain anatomy on MRI and normal postnatal neurological development.
  • Utilized the Cole-Green-LMS (CG-LMS) method for tracing reference centiles.

Main Results:

  • Established reference biometric centiles for key fetal brain structures: cerebrum, cerebellum, brain stem, and theca.
  • Demonstrated adequate overall interassessor agreement for all measurements.
  • Provided normative data for fetal brain development in the early second trimester.

Conclusions:

  • Reference biometric centiles for fetal brain structures (20-24 weeks gestation) serve as a reliable tool.
  • Facilitates accurate assessment of fetal brain development during this critical period.
  • Supports clinical evaluation and monitoring of prenatal neurodevelopment.