Fast and furious . . . or not, Plk4 dictates the pace
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Updated: Feb 13, 2026

Translational Rabbit Model of Chronic Cardiac Pacing
Published on: January 6, 2023
1Institut Curie, Paris Sciences et Lettres Research University, Centre National de la Recherche Scientifique, UMR144, Paris, France.
Abstract:
In each duplication cycle, daughter centrioles grow to the same length as their mothers. Which mechanisms regulate this fidelity to maintain centriole length is not known. In this issue, Aydogan et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801014) report a novel role for Polo-like kinase 4 (Plk4). They found that Plk4 functions in a homeostatic manner to balance growth rate and growth period to set the final centriole size.
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