[Stimulation of Brucella clearance in rats after treatment with BCG suspensions]

Intraperitoneal application of BCG induced a significantly increased clearance of Brucella in rats. The effect starts three days after application of 7 mg BCG to the rat and continued for eight weeks. This effect could be used for estimation of efficiency of BCG for nonspecific resistance stimulation. Comparative investigation of seven different batches reveals that three BCG preparations induce an unspecific resistance more than eight weeks, one for two weeks and three batches exerted no effect. Addition of Gelafusal as a stabilizer prolonged durability for about two weeks.