[Activation of human granulocytes and monocytes by physiologic concentrations of thiocyanate (rhodanide)]

The lytic activity of human granulocytes or monocytes against hyperimmune-anti B-sensitized erythrocyte targets is enhanced after a twenty hours preincubation in the presence of physiological serum concentrations of thiocyanate. An analogous pretreatment of effector cells has no influence on antibody-dependent lymphocyte-mediated cytotoxicity. Concentrations of thiocyanate corresponding to those found in human serum are without any effects when the ion is added immediately before starting of cell-mediated erythrocyte lysis.