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[Inhibitory serum factors in MLR and in PHA-stimulation in sera from normal, allogenic hyperimmunized and
Sera from normal, allogeneically hyperimmunized and transplantation tolerant mice show an inhibitory effect on MLR and PHA stimulation. After gel chromatography these inhibitory factors are preferably found in fraction III for MLR (MW 250-750 KD) and III and IV for PHA stimulation. These factors are not identical with the IL-2 inhibitor. A specific inhibitory component with a MW of about 1000 KD is found in sera from transplantation tolerant mice. This suppressor factor could have a synergistic function in induction of specificity and activity of suppressor cell.
Sera from normal, allogeneically hyperimmunized and transplantation tolerant mice show an inhibitory effect on MLR and PHA stimulation. After gel chromatography these inhibitory factors are preferably found in fraction III for MLR (MW 250-750 KD) and III and IV for PHA stimulation. These factors are not identical with the IL-2 inhibitor. A specific inhibitory component with a MW of about 1000 KD is found in sera from transplantation tolerant mice. This suppressor factor could have a synergistic function in induction of specificity and activity of suppressor cell.