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Related Experiment Video

Updated: Feb 13, 2026

A Murine Model of Carotid Aneurysm Formation

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Published on: September 9, 2025

CD40L Deficiency Protects Against Aneurysm Formation.

Pascal J H Kusters¹, Tom T P Seijkens^1,2, Linda Beckers¹

¹From the Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands (P.J.H.K., T.T.P.S., L.B., D.L., H.W., V.d.W., E.L.).

Arteriosclerosis, Thrombosis, and Vascular Biology

|March 10, 2018

Summary

Deficiency of CD40 ligand (CD40L) protects against aortic aneurysm formation and rupture in mice. This protection is linked to reduced inflammation and protease activity in the arterial wall, offering insights into aneurysm pathogenesis.

Keywords:

aneurysms angiotensin II cytokines inflammation matrix metalloproteinase 9

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Area of Science:

Cardiovascular Biology
Immunology
Vascular Biology

Background:

Arterial aneurysm formation mechanisms are not fully understood.
Inflammation is a key factor in aortic wall degeneration.
CD40 ligand (CD40L) is a major inflammatory driver.

Purpose of the Study:

To investigate the role of CD40L in aneurysm formation.
To determine if CD40L deficiency impacts aneurysm development and rupture.

Main Methods:

Transcriptomic analysis of human aneurysm samples.
Angiotensin II infusion in apolipoprotein E-deficient (Apoe-/-) and Cd40l-/-Apoe-/- mice.
Bone marrow chimera experiments.
Assessment of aneurysm incidence, rupture, and inflammatory markers.

Main Results:

CD40L and CD40 were upregulated in human aneurysms.
Cd40l-/-Apoe-/- mice showed significantly reduced rates of dissecting aneurysms (17-33%) compared to Apoe-/- mice (67-75%).
Lack of CD40L decreased inflammatory cell infiltration, proinflammatory cytokine expression, and matrix metalloproteinase activity, while increasing tissue inhibitor of metalloproteinase-3.

Conclusions:

Hematopoietic CD40L deficiency protects against dissecting aortic aneurysm formation and fatal rupture.
Reduced inflammation and protease activity in the arterial wall contribute to this protection.
CD40L is a critical mediator in aneurysm pathogenesis.