Related Experiment Video
Updated: Feb 13, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
How many ELNs are optimal for breast cancer patients with more than three PLNs who underwent MRM? A large
Xiaohui Wang1, Changbin Ji2, Huiying Chi3
1Research Service Office, Shandong Liaocheng People's Hospital, Liaocheng, China.
Background:
Few studies have focused on the optimal threshold of examed lymph nodes (ELNs) for breast cancer patients with more than three positive lymph nodes after modified radical mastectomy.
Materials And Methods:
The X-tile and the minimum P-value models were applied to determine the optimal threshold. Cox proportional hazard analysis was used to analyze the cancer-specific survival and perform subgroup analysis.
Results:
The results showed that 12 ELNs was the optimal threshold for these patients, and the patients with >12 ELNs had a better cancer-specific survival benefit compared with the patients with <12 ELNs (P<0.001).
Conclusion:
The number 12 can be selected as the optimal threshold of ELNs for breast cancer patients with >3 positive lymph nodes after modified radical mastectomy.
Related Concept Videos
What is Population Genetics?
What are Populations and Communities?
Conservation of Small Populations
Population Growth
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Optimal Foraging

