Related Experiment Video
Updated: Feb 13, 2026
07:45
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
54.7K
Self-Gated Late Gadolinium Enhancement at 7T to Image Rats with Reperfused Acute Myocardial Infarction.
Lei Wang1, Yushu Chen2, Bing Zhang2
1Molecular Imaging Center, West China Hospital of Sichuan University, Chengdu 610041, China.
Korean Journal of Radiology
|March 10, 2018
Summary
Self-gated (SG) cardiovascular magnetic resonance (CMR) imaging offers a viable alternative to ECG-gated methods for cardiac late gadolinium enhancement (LGE) in rats. This technique improves image quality and reduces acquisition time, proving effective for myocardial infarction/reperfusion studies.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Cardiac Imaging Techniques
- Animal Models in Research
Background:
- Electrocardiography (ECG)-trigger failures in cardiac magnetic resonance imaging (CMR) can prolong acquisition time (TA) and degrade image quality.
- Cardiac late gadolinium enhancement (LGE) imaging is crucial for assessing myocardial infarction/reperfusion injuries.
Purpose of the Study:
- To evaluate and optimize the self-gated (SG) cardiovascular magnetic resonance (CMR) technique for cardiac LGE imaging in a rat model of myocardial infarction/reperfusion.
- To compare the efficacy of SG-LGE with conventional ECG-triggered, respiration-gated (ECG-RESP-gating) methods.
Main Methods:
- Cardiovascular magnetic resonance images were acquired at 7T in 10 rats using both SG-LGE and ECG-RESP-gating methods.
- Various flip angles (FA: 10°-80°) and number of repetitions (NR: 40, 80, 150, 300) were tested for SG-LGE to determine optimal parameters.
- Image quality scores and contrast-to-noise ratio (CNR) were used to assess SG-LGE performance.
Main Results:
- SG-LGE successfully scanned all 10 rats (100%), whereas ECG-RESP-gating only succeeded in 4 rats (40%).
- Acquisition times for SG-LGE varied from 41 to 307 seconds based on NR, while the average TA for ECG-RESP-gating was 220 seconds.
- Optimal SG-LGE parameters included flip angles of 20°-30° and NR of 80, yielding high CNR and image quality scores.
Conclusions:
- The self-gated (SG) technique enhances cardiac late gadolinium enhancement (LGE) image quality without relying on irregular ECG or respiration gating.
- SG-LGE provides a reliable and effective alternative to conventional ECG-RESP-gating for cardiac LGE imaging in preclinical rat models.
Related Concept Videos
01:30Underflow Gates
420
Underflow gates are vital for controlling water flow in irrigation canals. The three main types of underflow gates — vertical, radial, and drum gates — serve different purposes while ensuring effective flow management. Vertical gates move up and down, generating a free-flowing water jet; radial gates pivot to regulate the flow; and drum gates rotate for precise adjustments. The flow through these gates is influenced by downstream conditions, resulting in free or drowned outflow.Free and...
420
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
4.1K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.1K
01:24Non-gated Ion Channels
8.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.3K
01:12Mechanically-gated Ion Channels
7.8K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.8K
01:11Design Example: Forces in Sluice Gate
3.1K
In hydraulic engineering, sluice gates are essential for managing water flow through channels, reservoirs, and irrigation systems. Sluice gates, acting as vertical barriers, regulate water by adjusting the gate's opening height, which changes the velocity and pressure of water flowing beneath the gate. Understanding the forces involved is crucial to designing sluice gates that can withstand dynamic pressure differences, especially when the gate is closed or partially open.
Key variables in...
Key variables in...
3.1K
03:00Self-Evaluation: Self-Enhancement and Self-Verification
5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K