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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
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Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?
Eros Marín1,2, Maria Cristina Cuturi1,2, Aurélie Moreau1,2
1Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.
Frontiers in Immunology
|March 10, 2018
Summary
Tolerogenic monocyte-derived dendritic cells (Tol-MoDCs) offer a promising cell therapy to induce specific immune tolerance in organ transplantation, potentially reducing reliance on broad immunosuppressive drugs and their associated risks.
Area of Science:
- Immunology
- Transplantation Science
- Cell Therapy
Background:
- Solid organ transplantation has advanced, but graft rejection persists without immunosuppressive drugs (IS).
- IS drugs prevent rejection but increase risks of cancer and infection due to their lack of specificity.
- Cell therapies present a novel approach to minimize IS use and achieve graft-specific tolerance.
Purpose of the Study:
- To review the characteristics and mechanisms of tolerogenic monocyte-derived dendritic cells (Tol-MoDCs) and rodent tolerogenic bone marrow-derived DCs (Tol-BMDCs).
- To discuss the potential of Tol-MoDCs in transplantation, building on evidence from rodent and non-human primate models.
- To explore the translation of Tol-MoDCs into clinical applications for transplantation.
Main Methods:
- Review of scientific literature on tolerogenic dendritic cells (Tol-DCs) and their application in transplantation models.
- Analysis of data from preclinical studies in rodents and non-human primates.
- Examination of ongoing and completed clinical trials involving Tol-MoDCs.
Main Results:
- Tolerogenic dendritic cells (Tol-DCs), particularly Tol-MoDCs, demonstrate the ability to induce specific antigen presentation and immune tolerance.
- Preclinical studies in rodents and non-human primates support the immunoregulatory potential of Tol-BMDCs in transplantation.
- Tol-MoDCs have shown safety in clinical trials for autoimmune diseases and are now being evaluated in early-phase transplantation trials.
Conclusions:
- Tolerogenic monocyte-derived dendritic cells (Tol-MoDCs) are a promising cell therapy for inducing allograft-specific tolerance in transplantation.
- Minimizing immunosuppressive drug use through cell therapy like Tol-MoDCs could improve long-term graft survival and patient safety.
- Further clinical evaluation of Tol-MoDCs in transplantation is warranted to establish their efficacy and widespread application.
Keywords:
autologous tolerogenic dendritic cellscell therapyclinical trialmechanismssafetytransplantationMore Related Videos
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