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Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions
Liv Eidsmo1,2, Elisa Martini1,2
1Department of Medicine Solna, Karolinska Institutet, Solna, Sweden.
Frontiers in Immunology
|March 10, 2018
Summary
Psoriasis involves skin inflammation and a localized disease memory. Langerhans cells (LCs) play a key role in psoriasis pathology, but their exact function requires further investigation.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Psoriasis is a common inflammatory skin condition characterized by distinct patches.
- Evidence suggests a localized 'disease memory' in resolved lesions, implicating tissue-resident immune cells.
- Langerhans cells (LCs) are strategically positioned to influence T cell responses and local tissue reactions in psoriasis.
Purpose of the Study:
- To provide an overview of current knowledge regarding Langerhans cells (LCs) in human psoriasis.
- To highlight the pro-inflammatory characteristics of LCs observed in psoriasis lesions.
- To review existing literature on conflicting data concerning LC localization and function in psoriasis.
Main Methods:
- Literature review of current knowledge on LCs in human psoriasis.
- Analysis of findings related to pro-inflammatory features of LCs.
- Examination of studies reporting conflicting data on LC localization and functionality.
Main Results:
- LCs exhibit pro-inflammatory features within psoriasis lesions.
- There is conflicting data in the literature regarding the precise localization and functionality of LCs in psoriasis.
- The role of LCs in maintaining disease memory in psoriasis is suggested.
Conclusions:
- LCs are key players in the pathology of psoriasis, exhibiting pro-inflammatory properties.
- Further research is necessary to clarify the conflicting data on LC localization and function.
- Elucidating the molecular mechanisms governing LC functionality is crucial for understanding inflammatory diseases like psoriasis.
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