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Cancer immunotherapy in patients with brain metastases

Salvatore Caponnetto1,2, Arianna Draghi3, Troels Holz Borch3,4

  • 1Cell Therapy Unit and Laboratory of Tumor Immunology, Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Cancer Immunology, Immunotherapy : CII
|March 10, 2018
PubMed

Insights

Immune checkpoint inhibitors show promise for treating brain metastases in cancer patients, offering hope for real-world scenarios. Further large-scale studies are needed to confirm these encouraging findings in diverse patient groups.

Area of Science:

  • Oncology
  • Immunology
  • Clinical Trials

Background:

  • Cancer immunotherapy clinical trials often exclude "real-world" patients.
  • Brain metastases affect a large fraction of cancer patients, yet trial data are scarce.
  • Lack of data hinders treatment decisions for patients with brain metastases.

Purpose of the Study:

  • To review the safety and efficacy of immune checkpoint inhibitors in patients with brain metastases.
  • To provide a clinical tool for "real-world" application.
  • To summarize current evidence for this underrepresented patient population.

Main Methods:

  • Literature review of available studies.
  • Focus on immune checkpoint inhibitors.
  • Inclusion of patients with cancer metastatic to the brain.

Main Results:

  • Encouraging evidence for intracranial objective responses.
  • Efficacy particularly noted in asymptomatic, previously untreated brain metastases.
  • Data suggest potential benefit in a "real-world" setting.

Conclusions:

  • Immune checkpoint inhibitors demonstrate potential for treating brain metastases.
  • Further prospective studies are essential to validate these findings.
  • These agents may offer a valuable therapeutic option for specific patient subgroups.
Keywords:
Brain metastasesCancer immunotherapyCheck-point inhibitorsIpilimumabNivolumabPembrolizumab

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