Related Experiment Video

Updated: Feb 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.8K

The association between serum vitamin B12 deficiency and tension-type headache in Turkish children

Mustafa Calik1, Mehmet Salih Aktas2, Emre Cecen3

  • 1Department of Pediatric Neurology, Harran University School of Medicine, 63200, Sanliurfa, Turkey. m.calik80@hotmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|March 10, 2018
PubMed

Insights

Children with tension-type headaches may have lower serum vitamin B12 levels. This study found significantly lower vitamin B12 in children experiencing headaches compared to healthy controls, suggesting a potential link.

Area of Science:

  • Neurology
  • Nutritional Science

Background:

  • Tension-type headache is a common neurological disorder.
  • Vitamin B12 deficiency has been implicated in various neurological conditions.

Purpose of the Study:

  • To investigate the association between serum vitamin B12 levels and tension-type headache in children.
  • To compare vitamin B12 levels in children with and without tension-type headache.

Main Methods:

  • Serum vitamin B12 levels were measured using electrochemiluminescence immunoassay (ECLIA).
  • Participants included 75 children with tension-type headache and 49 healthy controls.
  • Vitamin B12 deficiency was defined as < 200 pg/ml and severe deficiency as < 160 pg/ml.

Main Results:

  • Children with tension-type headache had significantly lower mean serum vitamin B12 levels (273.01 ± 76.77 pg/ml) compared to controls (316.22 ± 74.53 pg/ml) (p=0.003).
  • A higher percentage of children with headaches (24%) had vitamin B12 levels below 200 pg/ml versus controls (8%) (p=0.021).

Conclusions:

  • Serum vitamin B12 levels are significantly lower in children with tension-type headache.
  • An association between vitamin B12 levels and tension-type headache may exist, warranting further investigation.

Keywords:
AnxietyChildrenDepressionHeadacheVitamin B12 deficiency

More Related Videos

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children07:36

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children

Published on: September 1, 2018

40.4K
Portable Intermodal Preferential Looking IPL: Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism10:11

Portable Intermodal Preferential Looking IPL: Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism

Published on: December 14, 2012

19.1K

Related Concept Videos

Tension01:10

Tension

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a...
14.0K
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.5K
Surface Tension, Capillary Action, and Viscosity02:57

Surface Tension, Capillary Action, and Viscosity

Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
33.6K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.5K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.5K
Surface Tension of Fluid01:22

Surface Tension of Fluid

Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies...
1.6K