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Hashimoto's thyroiditis with elevated serum IgG4 concentrations is not equivalent to IgG4 Hashimoto's thyroiditis
1Department of Endocrinology, Peking University First Hospital, Beijing, China.
Clinical Endocrinology
|March 10, 2018
Summary
Elevated serum IgG4 in Hashimoto
Area of Science:
- Endocrinology and Immunology research focusing on autoimmune thyroid diseases.
Background:
- Hashimoto's thyroiditis (HT) can be categorized by serum immunoglobulin G4 (IgG4) levels or immunohistochemistry.
- Distinguishing between elevated serum IgG4 HT and IgG4 HT is crucial for understanding disease associations.
Purpose of the Study:
- To investigate the relationship between elevated serum IgG4 concentrations and IgG4-related HT.
- To determine if elevated serum IgG4 HT is equivalent to IgG4 HT.
Main Methods:
- Collected thyroid tissues and serum samples from 93 patients with HT.
- Measured serum levels of IgG, IgG4, and related antibodies (TgAb, TPOAb) using ELISAs.
- Detected IgG4, IgG, and TGF-β1 expression in thyroid tissues via immunohistochemistry.
Main Results:
- Elevated serum IgG4 HT group showed a significantly higher incidence of hypothyroidism (41.7%) compared to the nonelevated group (12.3%).
- No significant differences were observed in other serological markers or TGF-β1 expression between the groups.
- The frequency of patients meeting IgG4 HT diagnostic criteria was similar in both elevated and nonelevated serum IgG4 groups.
Conclusions:
- Elevated serum IgG4 is a marker for identifying HT patients with a higher risk of hypothyroidism.
- Elevated serum IgG4 concentration in HT does not equate to a diagnosis of IgG4-related HT.