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Neurodegenerative Process Linking the Eye and the Brain.
Raffaele Mancino1, Massimo Cesareo1, Alessio Martucci1
1Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Current Medicinal Chemistry
|March 10, 2018
Summary
Neurodegenerative diseases affect both the retina and central nervous system. Research explores how these conditions spread between the eye and brain, potentially using the retina as an early indicator.
Area of Science:
- Ophthalmology
- Neuroscience
- Pathology
Background:
- The retina and central nervous system (CNS) are interconnected in neurodegenerative diseases.
- The exact mechanisms causing this dual involvement remain unclear.
- Current theories include anterograde and retrograde transsynaptic neurodegeneration.
Purpose of the Study:
- To investigate the mechanisms of neurodegeneration affecting both the retina and CNS.
- To explore the retina as a potential window for observing CNS neurodegenerative processes.
Main Methods:
- Review of recent literature on neurodegenerative diseases affecting the visual pathway.
- Analysis of findings supported by novel neuroimaging techniques.
Main Results:
- Neuroimaging advancements facilitate study of both retinal and CNS components of the visual pathway.
- Evidence supports the role of transsynaptic degeneration in both directions between retina and CNS.
Conclusions:
- The retina and CNS are intrinsically linked in neurodegenerative conditions.
- Novel imaging techniques enhance understanding of these interconnected pathways.
- The retina may serve as a crucial diagnostic site for CNS neurodegenerative disorders.
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