Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

16.3K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
16.3K
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

11.7K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
11.7K
What is Natural Selection?01:32

What is Natural Selection?

129.8K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.8K
Antibiotic Selection00:57

Antibiotic Selection

60.2K
Overview
60.2K
Types of Selection01:46

Types of Selection

45.3K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
45.3K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Door-In-Door-Out Time Effect on Clinical Outcome According to Reperfusion Time in Endovascular Treatment.

Stroke (Hoboken, N.J.)·2026
Same author

Balloon-Expandable Stenting as a Bridging Therapy in Patients With Acute Stroke and Tandem Occlusions.

Stroke (Hoboken, N.J.)·2026
Same author

Proceedings of the Seventh Annual CLOTS Meeting: CLOTS 7.0, Madrid, Spain.

Stroke (Hoboken, N.J.)·2026
Same author

Acute Infarct Core Volume Estimation on Noncontrast Computed Tomography With a Deep Learning Algorithm.

Stroke (Hoboken, N.J.)·2026
Same author

Effect of the Cervical Lesion Severity on Procedural and Clinical Outcomes after Endovascular Treatment of Acute Tandem Lesions: A Multicenter Study.

Stroke (Hoboken, N.J.)·2026
Same author

Endovascular administration and magnetic retention of nanocapsules for improved brain delivery in large cerebral vascular models.

Nanoscale·2026

Related Experiment Video

Updated: Feb 13, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
09:57

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

2.4K

Apoptin, A Versatile Protein with Selective Antitumor Activity.

Jessica Castro1, Marc Ribo1, Antoni Benito1

  • 1Laboratori d`Enginyeria de Proteines, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Campus de Montilivi, Maria Aurelia Capmany 40, 17003, Girona, Spain.

Current Medicinal Chemistry
|March 10, 2018
PubMed
Summary
This summary is machine-generated.

Apoptin selectively kills cancer cells by inducing apoptosis, offering a promising avenue for antitumor chemotherapy. Further research is needed to optimize its delivery for clinical use.

Keywords:
ApoptinDNA damage responseantitumor drugapoptosiscancerviral protein.

More Related Videos

A Versatile Method of Patterning Proteins and Cells
09:57

A Versatile Method of Patterning Proteins and Cells

Published on: February 26, 2017

9.8K
An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter
10:08

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

Published on: May 21, 2021

4.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
09:57

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

2.4K
A Versatile Method of Patterning Proteins and Cells
09:57

A Versatile Method of Patterning Proteins and Cells

Published on: February 26, 2017

9.8K
An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter
10:08

An Economical and Versatile High-Throughput Protein Purification System Using a Multi-Column Plate Adapter

Published on: May 21, 2021

4.8K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Drug selectivity for cancer cells is a critical challenge in antitumor chemotherapy.
  • Apoptin, a protein, has emerged as a potential chemotherapeutic agent due to its ability to selectively eliminate cancer cells.
  • This protein has garnered significant scientific interest for its tumor-specific cytotoxic effects.

Purpose of the Study:

  • To review the cell death mechanisms induced by apoptin.
  • To explore strategies for enhancing apoptin's delivery to tumor cells.
  • To summarize the molecular basis of apoptin's tumor-selective cytotoxicity.

Main Methods:

  • Literature review of apoptin's cell death mechanisms.
  • Analysis of challenges in delivering apoptin to tumor cells due to aggregate formation.
  • Examination of approaches to improve apoptin's efficiency in cancer cells.

Main Results:

  • Apoptin induces selective apoptosis in tumor cells, sparing normal cells.
  • The protein's intrinsically disordered nature facilitates interactions with multiple cellular partners and pathways.
  • Functional motifs of apoptin are linked to its apoptosis-inducing mechanisms and tumor selectivity.

Conclusions:

  • Apoptin shows significant potential as a safe antitumor therapeutic agent.
  • Effective delivery methods for apoptin are crucial for its clinical application.
  • Continued research is necessary to overcome delivery challenges and translate apoptin into clinical practice.