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Updated: Feb 13, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins
1Protein Engineering, Biologics Research, Sanofi, Framingham, MA, 01701, United States.
Background:
Glycan-binding proteins are widely distributed in human and play an essential role in biological processes. Their involvements in inflammatory and immune responses make it increasingly likely that the glycan-binding proteins may represent valuable therapeutic targets.
Objective:
The current review aims to provide information on recent advancements in clinical developments of antibodies against glycan-binding proteins as potential targets.
Results And Conclusion:
There are several therapeutic antibodies being developed targeting glycanbinding proteins, including CD22, CD33, DEC-205, and CD62P, for different diseases. The clinical investigations demonstrated benefits of treatments with one antibody-drug conjugate against CD22 being approved by the regulatory agencies. The recent progresses in clinical developments of these antibodies have provided great promises in therapeutic targeting of more glycan-binding proteins for treating multiple diseases, including inflammation, autoimmune diseases, and hematological malignancies.
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