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Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
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Graphene Oxide as Scaffolds for Stem Cells: An Overview
M Duran1,2, A C M Luzo3, J G de Souza1
1Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP, Brazil.
Current Molecular Medicine
|March 10, 2018
Summary
Graphene oxide surfaces influence stem cell behavior, offering potential for tissue engineering. Optimizing graphene oxide platforms is key for controlling stem cell differentiation and proliferation, particularly for human adipose-derived stem cells.
Area of Science:
- Biomaterials Science
- Stem Cell Biology
- Tissue Engineering
Background:
- Graphene and graphene oxide (GO) topography significantly impact stem cell fate, including adhesion, differentiation, and proliferation.
- Developing novel graphene oxide stem cell culture platforms is crucial for advancing stem cell and tissue engineering applications.
Purpose of the Study:
- To review the effects of graphene oxide on stem cell behavior.
- To highlight the potential of graphene oxide films as platforms for modulating multipotent mesenchymal stem/stromal cells (MSCs), especially human adipose tissue-derived MSCs (AT-MSCs).
Main Methods:
- Literature review focusing on studies investigating graphene oxide's interaction with stem cells.
- Analysis of graphene oxide's influence on various differentiation pathways (osteogenesis, neurogenesis, oligodendrogenesis, adipogenesis, epithelial).
Main Results:
- Graphene oxide surfaces can effectively modulate the structure and function of MSCs and AT-MSCs.
- The implications of GO on multiple differentiation potentials of stem cells are discussed.
- GO toxicity and its specific effects on AT-MSCs proliferation and differentiation are examined.
Conclusions:
- Graphene oxide presents a promising biomaterial for stem cell culture and tissue engineering.
- Further research into GO surface design and manipulation is essential for optimizing stem cell applications.
- Understanding GO's impact on specific stem cell types like AT-MSCs is critical for therapeutic development.
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