Related Experiment Video

Updated: Feb 13, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K

Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Novel Therapy for Multidrug Resistant Gram Negative Infections in

Brittany A Rodriguez1,2, Jennifer E Girotto1,2,3, David P Nicolau4

  • 1Department of Pharmacy, Connecticut Children's Medical Center, Hartford, CT 06102, United States.

Current Pediatric Reviews
|March 10, 2018
PubMed

Insights

Multidrug-resistant gram-negative infections are a growing concern in children. This review examines Ceftazidime/Avibactam and Ceftolozane/Tazobactam, new antibiotics for pediatric use, given limited current data.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Pharmacology

Background:

  • Multidrug-resistant (MDR) infections, particularly MDR gram-negative bacteria, pose a significant global health threat.
  • Pediatric populations are increasingly affected by MDR organisms like P. aeruginosa, Enterobacteriaceae, and Acinetobacter spp.
  • Beta-lactamase production is a primary mechanism driving antimicrobial resistance.

Purpose of the Study:

  • To review the characteristics of Ceftazidime/Avibactam (CZA) and Ceftolozane/Tazobactam (C/T).
  • To explore the potential applications of CZA and C/T in pediatric patients.
  • To address the limited data available on these agents in children.

Main Methods:

  • Literature review of CZA and C/T.
  • Analysis of beta-lactamase inhibition mechanisms.
  • Examination of existing pediatric data and clinical trial information.

Main Results:

  • CZA and C/T are novel beta-lactam/beta-lactamase inhibitor combinations.
  • Both agents target specific MDR gram-negative pathogens.
  • Current pediatric data for CZA and C/T are scarce, necessitating further research.

Conclusions:

  • CZA and C/T represent important therapeutic options for MDR gram-negative infections.
  • Understanding their distinct properties is crucial for effective clinical application in children.
  • Further pediatric studies are essential to guide optimal use of these antibiotics.
Keywords:
Enterobacteriaceaebeta-lactam/beta-lactamase inhibitorceftazidime/avibactamceftolozane/tazobactamchildrenmultidrug resistance.

More Related Videos

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.7K
Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

11.4K

Related Concept Videos

Gram-negative Bacterial Protein Secretion Systems01:17

Gram-negative Bacterial Protein Secretion Systems

Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
1.0K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K