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Updated: Feb 13, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Small cell bladder carcinoma in age extremes: Report of two cases.]
Ana Vallejo-Benítez1, Enrique Rodríguez-Zarco1, Sara Pabón-Carrasco1
1Hospital Universitario Virgen Macarena. Sevilla. España.
Objective:
We report 2 cases of small cell neuroendocrine carcinomas (CCP) of the urinary bladder in patients aged 37 and 80 years. CCP is a malignancy with poor prognosis. We review the literature, under the current WHO classification (2016).
Methods:
Paraffin blocks were cut for HE staining and immunohistochemistry to analyze the expression of neuroendocrine differentiation.
Results:
The main diagnosis was based on histopathologic features, which revealed a diffuse growth pattern of small cells with scant cytoplasm and hyperchromatic nuclei. The result of the additional technical immunoreaction was positive for synaptophysin and CD56.
Conclusions:
Our cases have been reviewed with the literature to discuss the evolution and differential diagnosis of small cell carcinoma of the urinary bladder. This is a rare tumor with very aggressive behavior and its diagnosis lies in its morphology, and immunohistochemical profile.
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