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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Related Experiment Video

Updated: Feb 13, 2026

Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
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Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle

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Imaging Gliomas with Nanoparticle-Labeled Stem Cells.

Shuang-Lin Deng1, Yun-Qian Li1, Gang Zhao1

  • 1Department of Neurosurgical Oncology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Chinese Medical Journal
|March 10, 2018
PubMed
Summary

Combining stem cells with nanoparticles offers a novel approach for enhanced glioma imaging. This method improves tumor boundary visualization and shows promise for future glioma tracking and treatment strategies.

Keywords:
GliomaNanoparticleStem Cell

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Area of Science:

  • Neuro-oncology
  • Biomedical imaging
  • Nanotechnology

Background:

  • Gliomas are common central nervous system (CNS) neoplasms.
  • Traditional imaging techniques struggle to delineate tumor boundaries effectively.
  • Nanoparticles offer unique properties for therapeutic and diagnostic applications.

Purpose of the Study:

  • To review the basic understanding and clinical applications of combining stem cells and nanoparticles for glioma imaging.
  • To explore stem cells as a tracking mechanism for gliomas.
  • To evaluate nanoparticles as contrast agents in glioma imaging.

Main Methods:

  • Systematic literature search of PubMed up to 2017.
  • Keywords included: stem cell, glioma, nanoparticles, MRI, nuclear imaging, fluorescence imaging.
  • Focused on preclinical and basic studies of nanoparticle-labeled stem cells for glioma tracking.

Main Results:

  • Stem cells can be successfully labeled with various nanoparticles.
  • Nanoparticle-labeled stem cells demonstrate efficient migration to gliomas in different models.
  • The labeled cells produce signals detectable by multiple imaging modalities.

Conclusions:

  • Nanoparticle-labeled stem cells represent a promising platform for glioma imaging.
  • This approach facilitates both tracking and potential treatment of gliomas.
  • Further development could enhance diagnostic and therapeutic outcomes for CNS neoplasms.