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CD59: a promising target for tumor immunotherapy

Ronghua Zhang1, Qiaofei Liu1, Quan Liao1

  • 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China.

Future Oncology (London, England)
|March 10, 2018
PubMed

Insights

CD59, a complement inhibitor, is highly expressed in cancers and impacts immune cells within the tumor microenvironment. Modulating CD59 offers a promising strategy for cancer immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • CD59 is a glycosylphosphatidylinositol-anchored membrane protein that inhibits the membrane attack complex, regulating complement activation.
  • Elevated CD59 expression is observed in various cancer cell lines and tumor tissues.
  • CD59 influences immune cell function, infiltration, and phenotypes within the tumor microenvironment.

Purpose of the Study:

  • To review recent advancements in understanding CD59's functions and mechanisms in the tumor microenvironment.
  • To explore the potential of targeting CD59 for cancer immunotherapy.

Main Methods:

  • Literature review of recent studies on CD59 in cancer.
  • Analysis of CD59's role in complement regulation and immune cell modulation.
  • Synthesis of information on therapeutic strategies targeting CD59.

Main Results:

  • CD59 plays a significant role in regulating immune responses within the tumor microenvironment.
  • CD59 expression is linked to cancer progression and immune evasion.
  • Modulation of CD59 affects immune cell behavior and anti-tumor immunity.

Conclusions:

  • CD59 is a critical regulator in the tumor microenvironment with implications for cancer progression.
  • Targeting CD59 presents a potential therapeutic avenue for enhancing anti-tumor immunity and cancer immunotherapy.
Keywords:
CD59complementimmunotherapymicroenvironmenttumor

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