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Abemaciclib for the treatment of breast cancer

Takeshi Kotake1, Masakazu Toi1

  • 1a Department of Breast Surgery, Graduate School of Medicine , Kyoto University , Kyoto , Japan.

Expert Opinion on Pharmacotherapy
|March 10, 2018
PubMed
Abstract

Insights

Abemaciclib shows anti-tumor effects and manageable toxicity in HR-positive, HER2-negative breast cancer. Further research is needed to identify predictive biomarkers and confirm overall survival benefits.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Abemaciclib is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor targeting cell cycle regulation.
  • Numerous clinical trials have investigated CDK4/6 inhibitors, including abemaciclib, in various carcinomas, notably breast cancer.

Purpose of the Study:

  • To review available clinical data and ongoing trials of abemaciclib in breast cancer treatment.
  • To discuss the efficacy, safety, and future directions of abemaciclib therapy.

Main Methods:

  • Review of clinical trial data and published literature on abemaciclib in breast cancer.
  • Analysis of efficacy, toxicity, and biomarker data from clinical studies.

Main Results:

  • Abemaciclib demonstrates significant anti-tumor activity and manageable toxicity in HR-positive, HER2-negative breast cancer.
  • The drug is anticipated to become a standard therapy, though predictive biomarkers for response and tolerance are lacking.
  • Abemaciclib may have a unique effect on brain metastases, with preliminary positive cases reported.

Conclusions:

  • Abemaciclib is a promising targeted therapy for HR-positive, HER2-negative breast cancer.
  • Identification of predictive biomarkers is crucial for optimizing patient selection and treatment outcomes.
  • Further studies are required to establish the overall survival benefit and fully understand abemaciclib's role in managing brain metastases.
Keywords:
CDK4/6 inhibitorbiomarkerbrain metastaseshormone receptor positive breast cancertoxicity

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